HCID 178418361, 화합물 → HCID 178482270, 화합물

HRID 1410267노트

반응식

HRID 1410267 반응식
[N+:1]([C:4]1[C:5]([NH:28][CH3:29])=[CH:6][C:7]([O:23][CH2:24][CH:25]([F:27])[F:26])=[C:8]([CH:22]=1)[C:9]([NH:11][C@H:12]1[CH2:17][CH2:16][C@H:15]([C:18]([F:21])([F:20])[F:19])[CH2:14][CH2:13]1)=[O:10])([O-])=O.[H][H]>[Pd]>[NH2:1][C:4]1[C:5]([NH:28][CH3:29])=[CH:6][C:7]([O:23][CH2:24][CH:25]([F:26])[F:27])=[C:8]([CH:22]=1)[C:9]([NH:11][C@H:12]1[CH2:13][CH2:14][C@H:15]([C:18]([F:21])([F:20])[F:19])[CH2:16][CH2:17]1)=[O:10]

참가 물질

4

반응물 2

HCID 178418361HCID 178418361, 화합물HCID 178482271HCID 178482271, 화합물

생성물 1

HCID 178482270HCID 178482270, 화합물수율 98%

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

The sub-title compound was prepared from 5-nitro-2-(2,2-difluoroethoxy)-4-(methylamino)-N-(trans-4-trifluoromethyl-cyclohex-1-yl)-benzamide, hydrogen and Pd/C in analogy to example 86c.

출처 및 근거

ORD 기록
ord-40496cb079c94313aa102903498bbdc1
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08921405B2

반응 노트

불러오는 중…