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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1410528생성일: 2026년 10월 27일

m-(Trifluoromethyl)cinnamic acid → 2-[4-(1H-Indol-3-yl)-cyclohexylamino]-2-[1-(trans-3-{trifluoromethyl}-cinnamoyl)piperidin-4-yl]-acetamide

https://huagongshe.com/reaction/1410528

반응식

참여 물질

역할이름HCID투입량
반응물m-(Trifluoromethyl)cinnamic acidHCID 719451—
반응물2-[4-(1H-Indol-3-yl)-cyclohexylamino]-2-piperidin-4-yl-acetamide dihydrochlorideHCID 67775194—
생성물2-[4-(1H-Indol-3-yl)-cyclohexylamino]-2-[1-(trans-3-{trifluoromethyl}-cinnamoyl)piperidin-4-yl]-acetamideHCID 57343816—

반응 단계

The title compound was prepared from the product of Example 1, step J (142 mg, 0.333 mmol), and trans-3-(trifluoromethyl)-cinnamic acid, by the method of Example 1, step K, giving a gold solid that was mostly the more polar cyclohexyl diastereomer by LCMS. Mass spectrum (LCMS, ESI pos.) calcd. for C31H35F3N4O2: 553 (M+H). Found: 553.2.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08921559B2
출처 데이터셋uspto-grants-2014_12
ORD IDord-7b908c606f384ef28389f802a6784a8e
출처 메모uspto-grants-2014_12