2-Bicyclopropyl-2-yl-phenylamine → HCID 86685672, 화합물
반응식
[CH:1]1([CH:11]2[CH2:13][CH2:12]2)[CH2:3][CH:2]1[C:4]1[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=1[NH2:6].[H][H]>O1CCCC1.[Ru]>[CH:1]1([CH:11]2[CH2:13][CH2:12]2)[CH2:3][CH:2]1[CH:4]1[CH2:10][CH2:9][CH2:8][CH2:7][CH:5]1[NH2:6]참가 물질
5
실험 절차
0.289 g of Ru/C (5%) are added to a solution comprising 3.00 g (17.31 mmol) 2-[1,1′-Bi(cyclopropyl)-2-yl]anilin in 20 ml of tetrahydrofuran, and the mixture is hydrogenated with 100 bar of hydrogen at 120° C. for 20 hours. After cooling to room temperature, the catalyst is filtered off through Celite 545 and the product is concentrated under reduced pressure. This gives 3.01 g (96%) of 2-[1,1′-Bi(cyclopropyl)-2-yl]cyclohexanamine having a purity of 96% according to MSD-HPLC.
후처리
- filtrationthe catalyst is filtered off through Celite 545
- concentrationthe product is concentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-b5ff200b6de54b6691e82556b40935de
- 출처 데이터셋
- uspto-grants-2014_12
- 특허 번호
- US08921575B2
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