5-(Methylsulfonyl)-2-nitropyridine → 5-Methanesulfonylpyridin-2-amine
반응식
[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([N+:11]([O-])=O)=[N:9][CH:10]=1)(=[O:4])=[O:3]>CO.[Pd]>[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([NH2:11])=[N:9][CH:10]=1)(=[O:4])=[O:3]참가 물질
4
반응 조건
- 온도
- 25 °C
실험 절차
A mixture of 117b (2 g, 10 mmol), MeOH (10 mL), Pd/C (120 mg) in methanol (8 mL) was stirred fat 25° C. under H2 (50 Psi) overnight. The Pd/C was removed by filtration and the filtrate was concentrated under reduced pressure to give 117c (1.7 g, 98%). MS: [M+H]+ 173.
후처리
- customThe Pd/C was removed by filtration
- concentrationthe filtrate was concentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-683fc743864043229b1052b860d6e8b9
- 출처 데이터셋
- uspto-grants-2014_12
- 특허 번호
- US08921353B2
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