M-Phenylenediamine → 3-(3-Aminophenylamino)-5-bromo-1-methylpyrazin-2(1H)-one
반응식
Br[C:2]1[C:3](=[O:10])[N:4]([CH3:9])[CH:5]=[C:6]([Br:8])[N:7]=1.[C:11]1([NH2:18])[CH:16]=[CH:15][CH:14]=[C:13]([NH2:17])[CH:12]=1.C(N(CC)CC)C>C(O)(C)C>[NH2:17][C:13]1[CH:12]=[C:11]([NH:18][C:2]2[C:3](=[O:10])[N:4]([CH3:9])[CH:5]=[C:6]([Br:8])[N:7]=2)[CH:16]=[CH:15][CH:14]=1참가 물질
5
반응 조건
- 온도
- 80 °C
실험 절차
To a solution of 3,5-dibromo-1-methylpyrazin-2(1H)-one (536 mg, 2.0 mmol) and benzene-1,3-diamine (324 mg, 3.0 mmol) in isopropanol (18 mL) was added triethylamine (2.8 mL). The reaction mixture was stirred at 80° C. overnight. Then the mixture was evaporated under reduced pressure to afford 219a (480 mg, 81%) as a white solid. MS-ESI: [M+H]+ 295.0
후처리
- customThen the mixture was evaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-287c63844dbc43bb96d146d3c513eef3
- 출처 데이터셋
- uspto-grants-2014_12
- 특허 번호
- US08921353B2
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