Ammonium Hydroxide → 6-(Trifluoromethyl)pyridazin-3-amine
반응식
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:7]=1.[OH-].[NH4+:13]>C1COCC1>[F:9][C:8]([F:11])([F:10])[C:5]1[N:4]=[N:3][C:2]([NH2:13])=[CH:7][CH:6]=1참가 물질
4
반응 조건
- 온도
- 100 °C
실험 절차
A mixture of 3-chloro-6-trifluoromethylpyridazine (1.6 g, 8.80 mmol) and ammonium hydroxide (9 mL) in THF (3 mL) was heated at 100° C. in a microwave reactor for 1 h. After this period, the reaction mixture was evaporated and the residue was extracted with dichloromethane. The combined extract was dried over with MgSO4, filtered, and evaporated under reduce pressure to afford 301a (1.3 g, 93%) as a white solid. MS-ESI: [M+H]+ 164.1
후처리
- waitAfter this period
- customthe reaction mixture was evaporated
- extractionthe residue was extracted with dichloromethane
- extractionThe combined extract
- dry with materialwas dried over with MgSO4
- filtrationfiltered
- customevaporated
출처 및 근거
- ORD 기록
- ord-9e9fdb0f450b452a90aeaae5586db777
- 출처 데이터셋
- uspto-grants-2014_12
- 특허 번호
- US08921353B2
반응 노트
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