Carbon Dioxide → 5-Chloro-2-(methylthio)pyrimidine

HRID 1413043노트

반응식

HRID 1413043 반응식
[Cl:1][C:2]1[C:3](C(O)=O)=[N:4][C:5]([S:8][CH3:9])=[N:6][CH:7]=1.C(=O)=O>>[Cl:1][C:2]1[CH:3]=[N:4][C:5]([S:8][CH3:9])=[N:6][CH:7]=1

참가 물질

3

반응물 2

HCID 280Carbon DioxideHCID 7257115-Chloro-2-(methylsulfanyl)pyrimidine-4-carboxylic acid

생성물 1

HCID 47370635-Chloro-2-(methylthio)pyrimidine수율 89.2%

실험 절차

5-Chloro-2-methylthio-4-pyrimidine carboxylic acid (30 g) was heated at 180°-200° C. until all the solid had melted and the evolution of carbon dioxide had ceased (5 min). The residue was allowed to cool and then washed with several portions of chloroform. The chloroform washings were filtered to remove dark insoluble material and the filtrate was concentrated to give 5-chloro-2-methylthiopyrimidine as a pale brown crystalline solid (21 g, 89%), m.p. 55° C.

후처리

  1. custom(5 min)
  2. temperatureto cool
  3. washwashed with several portions of chloroform
  4. filtrationThe chloroform washings were filtered
  5. customto remove dark insoluble material
  6. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-97f3674f964e4f6c8af28d78938cc3ec
출처 데이터셋
uspto-grants-1981_02
특허 번호
US04248618

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