Boron tribromide → 5-(p-Hydroxyphenoxy)pyrimidine

HRID 1413052

반응식

HRID 1413052 반응식
C[O:2][C:3]1[CH:15]=[CH:14][C:6]([O:7][C:8]2[CH:9]=[N:10][CH:11]=[N:12][CH:13]=2)=[CH:5][CH:4]=1.B(Br)(Br)Br>ClCCl>[OH:2][C:3]1[CH:15]=[CH:14][C:6]([O:7][C:8]2[CH:13]=[N:12][CH:11]=[N:10][CH:9]=2)=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 25134Boron tribromideHCID 20292632HCID 20292632, 화합물

생성물 1

HCID 129406205-(p-Hydroxyphenoxy)pyrimidine수율 5.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

5-(p-Methoxyphenoxy)pyrimidine (7.7 g) was dissolved in dichloromethane and the solution, maintained at a temperature of -70° to -78° C., was treated by the dropwise addition of boron tribromide (7 ml). The stirred solution was allowed to warm to room temperature and after standing overnight the dichloromethane solution was washed with a cold saturated aqueous solution of sodium bicarbonate (100 ml). The dichloromethane solution was then dried, treated with charcoal and the solvent removed by distillation under reduced pressure. The residue was washed with diethyl ether to give 5-(p-hydroxyphenoxy)pyrimidine (0.4 g) m.p. 158° C. which was characterised by p.m.r. spectroscopy.

후처리

  1. temperaturethe solution, maintained at a temperature of -70° to -78° C.
  2. washthe dichloromethane solution was washed with a cold saturated aqueous solution of sodium bicarbonate (100 ml)
  3. dry with materialThe dichloromethane solution was then dried
  4. additiontreated with charcoal
  5. customthe solvent removed by distillation under reduced pressure
  6. washThe residue was washed with diethyl ether

출처 및 근거

ORD 기록
ord-2ca862c074ec497ea11bc0de5bcc83e4
출처 데이터셋
uspto-grants-1981_02
특허 번호
US04248618

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