Thionyl Chloride → 7-Ethylsulfonyl-1,4-benzodioxane-5-carbonyl chloride

HRID 1413140

반응식

HRID 1413140 반응식
S(Cl)([Cl:3])=O.[CH2:5]([S:7]([C:10]1[CH:11]=[C:12]([C:20]([OH:22])=O)[C:13]2[O:18][CH2:17][CH2:16][O:15][C:14]=2[CH:19]=1)(=[O:9])=[O:8])[CH3:6]>CN(C)C=O>[CH2:5]([S:7]([C:10]1[CH:11]=[C:12]([C:20]([Cl:3])=[O:22])[C:13]2[O:18][CH2:17][CH2:16][O:15][C:14]=2[CH:19]=1)(=[O:9])=[O:8])[CH3:6]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 205447587-Ethylsulfonyl-1,4-benzodioxane-5-carboxylic acid

생성물 1

HCID 205447287-Ethylsulfonyl-1,4-benzodioxane-5-carbonyl chloride수율 100%

시약·촉매·용매 1

HCID 6228Dimethylformamide촉매

실험 절차

243 g of thionyl chloride, a few drops of dimethyl formamide and 139 g of 7-ethylsulfonyl-1,4-benzodioxane-5-carboxylic acid were introduced into a balloon flask provided with a condenser. The mixture was heated and then the thionyl chloride in excess was distilled off under vacuum. 148 g of 7-ethylsulfonyl-1,4-benzodioxane-5-carbonyl chloride were obtained (M.P.: 146°-147° C.; yield: 100%).

후처리

  1. customprovided with a condenser
  2. temperatureThe mixture was heated
  3. distillationthe thionyl chloride in excess was distilled off under vacuum

출처 및 근거

ORD 기록
ord-cb2469987a0449588e960e7911da49bd
출처 데이터셋
uspto-grants-1981_02
특허 번호
US04248885

연결된 노트

불러오는 중…