Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Aminomethyl-1-ethylpyrrolidine → N-(1-ethyl-2-pyrrolidylmethyl)-7-ethylsulfonyl-1,4-benzodioxane-5-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Aminomethyl-1-ethylpyrrolidine | HCID 117295 | — |
| 반응물 | 7-Ethylsulfonyl-1,4-benzodioxane-5-carbonyl chloride | HCID 20544728 | — |
| 생성물 | N-(1-ethyl-2-pyrrolidylmethyl)-7-ethylsulfonyl-1,4-benzodioxane-5-carboxamide | HCID 20293650 | 69.8% |
반응 단계
In a similar manner 64.5 g of dextrorotary-1-ethyl-2-aminomethylpyrrolidine was reacted with 146 g of 7-ethylsulfonyl-1,4-benzodioxane-5-carbonyl chloride to give, after treatment and purification, 133.5 g of dextrorotatory N-(1-ethyl-2-pyrrolidylmethyl)-7-ethylsulfonyl-1,4-benzodioxane-5-carboxamide (M.P.: 111°-112° C.; yield: 69.8%); (α)D20 =55.5° (in 5% solution in dimethylformamide).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04248885 |
| 출처 데이터셋 | uspto-grants-1981_02 |
| ORD ID | ord-4ea498dbfb854b9fa9e5efd4ea6e8bce |
| 출처 메모 | uspto-grants-1981_02 |