5-Fluorouracil → 1,3-Bis(tetrahydro-2-furanyl)-5-fluoro-2,4-pyrimidinedione

HRID 1413196

반응식

HRID 1413196 반응식
[F:1][C:2]1[C:3](=[O:9])[NH:4][C:5](=[O:8])[NH:6][CH:7]=1.[O:10]1[CH:14]=[CH:13][CH2:12][CH2:11]1>N1C=CC=CC=1>[O:10]1[CH2:11][CH2:12][CH2:13][CH:14]1[N:6]1[CH:7]=[C:2]([F:1])[C:3](=[O:9])[N:4]([CH:11]2[CH2:12][CH2:13][CH2:14][O:10]2)[C:5]1=[O:8]

참가 물질

4

반응물 2

HCID 33855-FluorouracilHCID 709342,3-Dihydrofuran

생성물 1

HCID 1249561,3-Bis(tetrahydro-2-furanyl)-5-fluoro-2,4-pyrimidinedione

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
150 °C

실험 절차

In 20.8 ml of pyridine were dissolved 5.2 g (40 m mol) of 5-fluorouracil and 14 g (200 m mol) of 2,3-dihydrofuran. The solution were heated at about 150° C. in a closed tubular reactor under agitation for 6 hours. After the reaction, the reaction mixture was concentrated to dryness under reduced pressure. The residue was dissolved in chloroform and the solution was passed through a column of silica gel. The column was eluated with chloroform and the effluent was concentrated to dryness under reduced pressure. The residue was washed with a small amount of petroleum ether to give the above-mentioned compound as colorless crystals.

후처리

  1. customAfter the reaction
  2. concentrationthe reaction mixture was concentrated to dryness under reduced pressure
  3. dissolutionThe residue was dissolved in chloroform
  4. concentrationthe effluent was concentrated to dryness under reduced pressure
  5. washThe residue was washed with a small amount of petroleum ether

출처 및 근거

ORD 기록
ord-2992a554a28e4ff7a9ce0121c7aa404d
출처 데이터셋
uspto-grants-1981_02
특허 번호
US04249006

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