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Potassium Carbonate → 2-Cyclopentyl-6,7-dichloro-2-methyl-5-trifluoromethylsulfonyloxy-1-indanone

HRID 1413234
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HRID 1413234 반응식
[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]2[C:5]([CH2:6][C:7]([CH:14]3[CH2:18][CH2:17][CH2:16][CH2:15]3)([CH3:13])[C:8]2=[O:12])=[CH:4][C:3]=1[OH:19].C(=O)([O-])[O-].[K+].[K+].[F:26][C:27]([F:33])([F:32])[S:28](Cl)(=[O:30])=[O:29]>CC(C)=O>[CH:14]1([C:7]2([CH3:13])[CH2:6][C:5]3[C:9](=[C:10]([Cl:11])[C:2]([Cl:1])=[C:3]([O:19][S:28]([C:27]([F:33])([F:32])[F:26])(=[O:30])=[O:29])[CH:4]=3)[C:8]2=[O:12])[CH2:18][CH2:17][CH2:16][CH2:15]1
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참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 79000Trifluoromethanesulfonyl chlorideHCID 123955886,7-Dichloro-2-cyclopentyl-5-hydroxy-2-methylindan-1-one

생성물 1

HCID 125402562-Cyclopentyl-6,7-dichloro-2-methyl-5-trifluoromethylsulfonyloxy-1-indanone

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 6,7-dichloro-2-cyclopentyl-5-hydroxy-2-methyl-1-indanone (20.93 g., 0.07 mole), anhydrous potassium carbonate (25.99 g., 0.188 mole) and dry acetone (350 ml) are stirred at room temperature and treated with trifluoromethane sulfonyl chloride (12.70 g., 0.0754 mmole) in portions. Reaction is complete in about 15 minutes after the completion of the addition. The mixture is filtered and evaporated to dryness. The residue is dissolved in methylene chloride, the solution dried (MgSO4) and evaporated under vacuum to an oil giving 28.45 g. (94%),

후처리

  1. customReaction
  2. additionafter the completion of the addition
  3. filtrationThe mixture is filtered
  4. customevaporated to dryness
  5. dissolutionThe residue is dissolved in methylene chloride
  6. dry with materialthe solution dried (MgSO4)
  7. customevaporated under vacuum to an oil
  8. customgiving 28.45 g

출처 및 근거

ORD 기록
ord-2ccae35062f5413eba9527c665b3537e
출처 데이터셋
uspto-grants-1981_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04249021

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