Dichloroacetyl chloride → HCID 13309297, 화합물

HRID 1413309노트

반응식

HRID 1413309 반응식
[CH:1]([NH:4][CH2:5][C:6]#[CH:7])([CH3:3])[CH3:2].C(N(CC)CC)C.[Cl:15][CH:16]([Cl:20])[C:17](Cl)=[O:18]>C1(C)C=CC=CC=1>[CH:1]([N:4]([CH2:5][C:6]#[CH:7])[C:17](=[O:18])[CH:16]([Cl:20])[Cl:15])([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 6593Dichloroacetyl chlorideHCID 8471TriethylamineHCID 243521N-(Propan-2-yl)prop-2-yn-1-amine

생성물 1

HCID 13309297HCID 13309297, 화합물수율 84.7%

시약·촉매·용매 1

HCID 1140Toluene용매2회

실험 절차

118 g of isopropylpropargylamine and 123 g of triethylamine are dissolved in 670 ml of toluene. While cooling and at room temperature, a solution of 180 g of dichloroacetyl chloride in 450 ml of toluene is dripped into this solution. The mixture is allowed to react for 1 hour before being filtered, and the filtrate is washed with water. The residue remaining after removal of the solvent is washed with petroleum ether. There is obtained 214 g (84% of theory) of N-isopropyl-N-propargyldichloroacetamide; b.p. (0.013 mbar):80°-82° C.; m.p.: 58°-59° C.

후처리

  1. customto react for 1 hour
  2. filtrationbefore being filtered
  3. washthe filtrate is washed with water
  4. customafter removal of the solvent
  5. washis washed with petroleum ether

출처 및 근거

ORD 기록
ord-fbaaeb3a9bd44a53a52906b5f86e2b40
출처 데이터셋
uspto-grants-1981_02
특허 번호
US04249933

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