Water → p-Chlorophenyl-5-methoxymethyl oxazolidine

HRID 1413321노트

반응식

HRID 1413321 반응식
[NH2:1][CH2:2][CH:3]([OH:7])[CH2:4][O:5][CH3:6].[Cl:8][C:9]1[CH:16]=[CH:15][C:12]([CH:13]=O)=[CH:11][CH:10]=1.O>C1C=CC=CC=1>[Cl:8][C:9]1[CH:16]=[CH:15][C:12]([CH:13]2[NH:1][CH2:2][CH:3]([CH2:4][O:5][CH3:6])[O:7]2)=[CH:11][CH:10]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 77264-ChlorobenzaldehydeHCID 1245101-Amino-3-methoxypropan-2-ol

생성물 1

HCID 20291464p-Chlorophenyl-5-methoxymethyl oxazolidine

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

Twelve and six tenths (12.6) grams of 1-amino-3-methoxy-2-propanol and 16.9 grams of p-chlorobenzaldehyde were combined in 150 milliliters of benzene and heated to reflux under a modified Dean-Stark apparatus until about 2.5 milliliters of water were azeotropically removed. An additional 50 milliliters of benzene was distilled over and the mixture was cooled to room temperature and the volume was adjusted to 109.2 milliliters, so that 4 milliliters=1 gram of intermediate. Aliquots of this solution were used in subsequent reactions.

후처리

  1. temperatureheated
  2. customwere azeotropically removed
  3. distillationAn additional 50 milliliters of benzene was distilled over and the mixture

출처 및 근거

ORD 기록
ord-35d95240b84540b8ac36cee8bc7d2717
출처 데이터셋
uspto-grants-1981_02
특허 번호
US04249931

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