m-Chloroperbenzoic acid → 3-Bromo-2-(methoxycarbonylamino)-6-phenylsulfinyl imidazo [1,2-a] pyridine

HRID 1413434노트

반응식

HRID 1413434 반응식
[Br:1][C:2]1[N:6]2[CH:7]=[C:8]([S:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:9]=[CH:10][C:5]2=[N:4][C:3]=1[NH:18][C:19]([O:21][CH3:22])=[O:20].ClC1C=CC=C(C(OO)=[O:31])C=1>ClCCl>[Br:1][C:2]1[N:6]2[CH:7]=[C:8]([S:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[O:31])[CH:9]=[CH:10][C:5]2=[N:4][C:3]=1[NH:18][C:19]([O:21][CH3:22])=[O:20]

참가 물질

4

반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 544631513-Bromo-2(methoxycarbonylamino)-6(phenylthio) imidazo [1,2-a] pyridine

생성물 1

HCID 538100123-Bromo-2-(methoxycarbonylamino)-6-phenylsulfinyl imidazo [1,2-a] pyridine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Alternatively, one may treat a suspension of 3-bromo-2(methoxycarbonylamino)-6(phenylthio) imidazo [1,2-a] pyridine (1.0 gm. 2.64 mmoles) in 100 ml. of dichloromethane with 85% metachloroperbenzoic acid (464 mg., 2.64 mmoles). After 1 hour at room temperature, the solution is washed with aqueous saturated sodium bicarbonate solution, and with water. After drying the solvent is removed in vacuo and the residue is chromatographed over silica gel to yield 3-bromo-2-(methoxycarbonylamino)-6-phenylsulfinyl imidazo [1,2-a] pyridine m.p. 150°-152° C.

후처리

  1. additionAlternatively, one may treat
  2. washthe solution is washed with aqueous saturated sodium bicarbonate solution
  3. customAfter drying the solvent
  4. customis removed in vacuo
  5. customthe residue is chromatographed over silica gel

출처 및 근거

ORD 기록
ord-9b47318919064db39001fc0a3072aa2a
출처 데이터셋
uspto-grants-1981_02
특허 번호
US04250174

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