Phosphorus pentachloride → HCID 12901645, 화합물

HRID 1413438노트

반응식

HRID 1413438 반응식
[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[C:5]([C:10]([OH:12])=O)=[CH:4][N:3]=1.P(Cl)(Cl)(Cl)(Cl)[Cl:14]>C(OCC)C>[ClH:14].[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[C:5]([C:10]([Cl:14])=[O:12])=[CH:4][N:3]=1

참가 물질

4

반응물 2

HCID 24819Phosphorus pentachlorideHCID 128289592-Amino-4-methoxypyrimidine-5-carboxylic acid

생성물 1

HCID 12901645HCID 12901645, 화합물

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To 16.9 g of 2-amino 4-methoxy 5-pyrimidinyl carboxylic acid prepared in stage 2, in suspension in 300 ml of anhydrous ethyl ether, were added at 0° C., 20.8 g of phosphorous pentachloride while stirring. After returning to room temperature for 3 hours, the precipitate was separated by filtration, rinsed several times with 50 ml of absolute ethyl ether. The hydrochloride of the 2-amino 4-methoxy 5-chlorocarbonyl pyrimidine thus obtained was used in the raw state in the following stage.

후처리

  1. customthe precipitate was separated by filtration
  2. washrinsed several times with 50 ml of absolute ethyl ether

출처 및 근거

ORD 기록
ord-e5e9dcf3a4c2432699fbb661ca6a4b19
출처 데이터셋
uspto-grants-1981_02
특허 번호
US04250178

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