Thionyl Chloride → 2-Chloro-4-trifluoromethyl-5-thiazolecarbonyl chloride

HRID 1413641노트

반응식

HRID 1413641 반응식
[Cl:1][C:2]1[S:3][C:4]([C:11]([OH:13])=O)=[C:5]([C:7]([F:10])([F:9])[F:8])[N:6]=1.S(Cl)([Cl:16])=O>>[Cl:1][C:2]1[S:3][C:4]([C:11]([Cl:16])=[O:13])=[C:5]([C:7]([F:10])([F:9])[F:8])[N:6]=1

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 132827432-Chloro-4-(trifluoromethyl)-1,3-thiazole-5-carboxylic acid

생성물 1

HCID 132827442-Chloro-4-trifluoromethyl-5-thiazolecarbonyl chloride

실험 절차

A mixture of 36.0 g (0.1554 mole) of the acid of Example 7 and 171 g (1.437 mole) of thionyl chloride were held at reflux for 6 hours. Excess thionyl chloride was removed under reduced pressure and the residue (38.1 g, 98%) was reacted as described in Examples 9-14.

후처리

  1. temperatureat reflux for 6 hours
  2. customExcess thionyl chloride was removed under reduced pressure
  3. customthe residue (38.1 g, 98%) was reacted

출처 및 근거

ORD 기록
ord-4a6fd126b8154b37b374b110c37da39d
출처 데이터셋
uspto-grants-1981_02
특허 번호
US04251261

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