2-(2-Fluoro-4-trifluoromethylphenylamino)-3-methylbutanoic acid → 3-(3-Fluorobenzyl)-pyrrolylmethyl 2-(2-fluoro-4-trifluoromethylphenylamino)-3-methylbutanoate

HRID 1413974노트

반응식

HRID 1413974 반응식
[F:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[NH:12][CH:13]([CH:17]([CH3:19])[CH3:18])[C:14]([OH:16])=[O:15].[F:20][C:21]1[CH:22]=[C:23]([CH:32]=[CH:33][CH:34]=1)[CH2:24][C:25]1[CH:29]=[CH:28][NH:27][C:26]=1[CH2:30]O>>[F:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[NH:12][CH:13]([CH:17]([CH3:19])[CH3:18])[C:14]([O:16][CH2:30][C:26]1[NH:27][CH:28]=[CH:29][C:25]=1[CH2:24][C:23]1[CH:32]=[CH:33][CH:34]=[C:21]([F:20])[CH:22]=1)=[O:15]

참가 물질

3

반응물 2

HCID 202839832-(2-Fluoro-4-trifluoromethylphenylamino)-3-methylbutanoic acidHCID 545232793-(3-Fluorobenzyl)-pyrrolylmethyl alcohol

생성물 1

HCID 202892963-(3-Fluorobenzyl)-pyrrolylmethyl 2-(2-fluoro-4-trifluoromethylphenylamino)-3-methylbutanoate

실험 절차

The acid chloride of 2-(2-fluoro-4-trifluoromethylphenylamino)-3-methylbutanoic acid is reacted with 3-(3-fluorobenzyl)-pyrrolylmethyl alcohol using the procedure of Example 1 to give 3-(3-fluorobenzyl)-pyrrolylmethyl 2-(2-fluoro-4-trifluoromethylphenylamino)-3-methylbutanoate.

출처 및 근거

ORD 기록
ord-da00b588098340c19db3706f73ae57a3
출처 데이터셋
uspto-grants-1981_02
특허 번호
US04252724

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