Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetonitrile → cis-N-Carbobenzyloxy-4-[[(methylamino)carbonyl]oxy]-L-proline, methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetonitrile | HCID 6342 | — |
| 반응물 | Methyl Isocyanate | HCID 12228 | — |
| 반응물 | (2S,4S)-1-Benzyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate | HCID 688413 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | cis-N-Carbobenzyloxy-4-[[(methylamino)carbonyl]oxy]-L-proline, methyl ester | HCID 131711848 | 86% |
반응 단계
To a stirred solution of 5.4 g. (0.019 mole) of N-carbobenzyloxy-cis-4-hydroxy-L-proline, methyl ester, in 120 ml. of acetonitrile is added 5.4 ml. of triethylamine, followed by 5.4 ml. of methyl isocyanate. After keeping overnight at room temperature and refluxing for two hours, the reaction mixture is worked up as in Example 1c to give 5.6 g (86%) of a pale yellow viscous oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04252943 |
| 출처 데이터셋 | uspto-grants-1981_02 |
| ORD ID | ord-8429242f70824658bcd09f99cb2a2e7f |
| 출처 메모 | uspto-grants-1981_02 |