Tetrahydrofuran → HCID 53867664, 화합물

HRID 1414090노트

반응식

[S:1](Cl)(Cl)(=[O:3])=[O:2].[NH:6]([C:8]1[CH:17]=[CH:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]=1)[NH2:7].C(N([CH2:23][CH3:24])CC)C.O1[CH2:29][CH2:28][CH2:27][CH2:26]1>>[CH2:26]([N:7]([S:1]([C:24]1[CH:23]=[CH:13][CH:12]=[CH:11][CH:10]=1)(=[O:3])=[O:2])[NH:6][C:8]1[CH:17]=[CH:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]=1)[CH2:27][CH2:28][CH2:29][CH2:26][CH2:27][CH2:28][CH2:29][CH2:14][CH2:15][CH2:16][CH3:17]

참가 물질

반응물 4

HCID 8028Tetrahydrofuran2회

HCID 8471Triethylamine

HCID 24648Sulfuryl chloride

HCID 85111Quinoline, 2-hydrazinyl-

생성물 1

HCID 53867664HCID 53867664, 화합물

실험 절차

To a solution of the sulfonyl chloride in 10 ml tetrahydrofuran was added a solution of the hydrazinoquinoline and triethylamine in 30 ml tetrahydrofuran (4 ml dimethylformamide was included to aid solubility). The temperature of the reaction mixture was maintained below 10° C. during the addition and for 30 minutes thereafter while the mixture was continuously stirred. The product was recovered as in Example 1 yielding 8.4 g of a tan solid. NMR and IR analysis confirmed the product to be 2-(dodecylbenzenesulfonylhydrazino)quinoline.

후처리

temperatureThe temperature of the reaction mixture was maintained below 10° C. during the addition and for 30 minutes
customThe product was recovered as in Example 1 yielding 8.4 g of a tan solid

출처 및 근거

ORD 기록: ord-41a88024ab7e41cb80ab666e8ac9a35a
출처 데이터셋: uspto-grants-1981_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04252959

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