Thionyl Chloride → 6-Methoxy-2-aminobenzthiazole hydrochloride

HRID 1414106

반응식

HRID 1414106 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]([NH2:12])=[S:11])=[CH:5][CH:4]=1.S(Cl)([Cl:15])=O>C1(C)C=CC=CC=1>[ClH:15].[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[N:9]=[C:10]([NH2:12])[S:11][C:7]=2[CH:8]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 6675494-Thioureidoanisole

생성물 1

HCID 202899826-Methoxy-2-aminobenzthiazole hydrochloride

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
110 °C

실험 절차

182 Parts of 4-methoxyphenyl-thiourea are suspended in 900 parts of toluene; 310 parts of thionyl chloride are added over a period of 1 hour at 20° to 30° C. The temperature of the mixture is then uniformly raised to 110° C. within 2 hours while stirring, stirring is continued for 2 hours under reflux, 20 parts of kieselguhr are added and the toluene is distilled off by blowing in steam. The solution of 6-methoxy-2-aminobenzthiazole hydrochloride obtained is clarified by adding 5 parts of charcoal, filtered and the clear filtrate is added to 175 parts of 25% aqueous ammonia solution.

후처리

  1. stirringstirring
  2. temperatureunder reflux
  3. addition20 parts of kieselguhr are added
  4. distillationthe toluene is distilled off

출처 및 근거

ORD 기록
ord-e2d8ca958a694cac9fddf477a37e51d1
출처 데이터셋
uspto-grants-1981_02
특허 번호
US04252963

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