Tert-Butylamine → 1-{4-[2-(Cyclopropylmethoxy)-ethoxy]phenoxy}-3-t-butylamino-propan-2-ol

HRID 1414141노트

반응식

HRID 1414141 반응식
[CH:1]1([CH2:4][O:5][CH2:6][CH2:7][O:8][C:9]2[CH:19]=[CH:18][C:12]([O:13][CH2:14][CH:15]3[O:17][CH2:16]3)=[CH:11][CH:10]=2)[CH2:3][CH2:2]1.[C:20]([NH2:24])([CH3:23])([CH3:22])[CH3:21]>>[CH:1]1([CH2:4][O:5][CH2:6][CH2:7][O:8][C:9]2[CH:19]=[CH:18][C:12]([O:13][CH2:14][CH:15]([OH:17])[CH2:16][NH:24][C:20]([CH3:23])([CH3:22])[CH3:21])=[CH:11][CH:10]=2)[CH2:3][CH2:2]1

참가 물질

3

반응물 2

HCID 6385Tert-ButylamineHCID 150353032-((4-(2-(Cyclopropylmethoxy)ethoxy)phenoxy)methyl)oxirane

생성물 1

HCID 30474911-{4-[2-(Cyclopropylmethoxy)-ethoxy]phenoxy}-3-t-butylamino-propan-2-ol수율 74%

실험 절차

Following the procedure of Example I, 1-{4-[2-(cyclopropylmethoxy)-ethoxy]-phenoxy}-2,3-epoxy-propane is prepared and then treated with t-butylamine. 7.6 g (yield=74%) of crude 1{4-[2-(cyclopropylmethoxy)-ethoxy]phenoxy}-3-t-butylamino-propan-2-ol are thus obtained, and this material is converted to the fumarate by mixing stoichiometric amounts of the base and of the acid in solution in isopropanol. The neutral fumarate which has precipitated is filtered off and recrystallised from ethanol (yield=80%), M.p.=158°-160° C.

후처리

  1. customis prepared

출처 및 근거

ORD 기록
ord-f387247248f440b5b9fa891ab88fa247
출처 데이터셋
uspto-grants-1981_02
특허 번호
US04252984

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