2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline → 4-Amino-6,7-dimethoxy-2-[4-(2-methyloxazole-4-carbonyl)piperazin-1-yl]quinazoline Hydrochloride
반응식
[CH3:1][C:2]1[O:3][CH:4]=[C:5]([C:7]([Cl:9])=[O:8])[N:6]=1.[NH2:10][C:11]1[C:20]2[C:15](=[CH:16][C:17]([O:23][CH3:24])=[C:18]([O:21][CH3:22])[CH:19]=2)[N:14]=[C:13]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[N:12]=1>O1CCOCC1>[ClH:9].[NH2:10][C:11]1[C:20]2[C:15](=[CH:16][C:17]([O:23][CH3:24])=[C:18]([O:21][CH3:22])[CH:19]=2)[N:14]=[C:13]([N:25]2[CH2:30][CH2:29][N:28]([C:7]([C:5]3[N:6]=[C:2]([CH3:1])[O:3][CH:4]=3)=[O:8])[CH2:27][CH2:26]2)[N:12]=1참가 물질
4
실험 절차
A solution of 2-methyloxazole-4-carbonyl chloride (1.01 g., 6.9 mmole) in dioxane was added to a solution of 4-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline (2.00 g., 6.9 mmole) in dioxane. The mixture was heated at reflux for 2 hours. Filtration gave the title compound having a m.p. of 278°-280° C. with decomposition after recrystallization from methanol.