2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline → 62412-39-9

HRID 1414238노트

반응식

HRID 1414238 반응식
[CH3:1][S:2][C:3]1[O:7][C:6]([C:8]([Cl:10])=[O:9])=[N:5][N:4]=1.[NH2:11][C:12]1[C:21]2[C:16](=[CH:17][C:18]([O:24][CH3:25])=[C:19]([O:22][CH3:23])[CH:20]=2)[N:15]=[C:14]([N:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)[N:13]=1>O1CCOCC1>[ClH:10].[NH2:11][C:12]1[C:21]2[C:16](=[CH:17][C:18]([O:24][CH3:25])=[C:19]([O:22][CH3:23])[CH:20]=2)[N:15]=[C:14]([N:26]2[CH2:31][CH2:30][N:29]([C:8]([C:6]3[O:7][C:3]([S:2][CH3:1])=[N:4][N:5]=3)=[O:9])[CH2:28][CH2:27]2)[N:13]=1

참가 물질

4

반응물 2

HCID 6162672-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazolineHCID 135447285-(Methylsulfanyl)-1,3,4-oxadiazole-2-carbonyl chloride

생성물 1

HCID 1594277762412-39-9수율 99.2%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

A solution of 5-methylthio-1,3,4-oxadiazole-2-carbonyl chloride (0.601 g., 3.36 mmole) in dioxane (10 ml.) was added to a solution of 4-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline (0.972 g., 3.36 mmole) in dioxane (100 ml.). The resultant mixture was stirred at room temperature for 65 hours, then was heated at reflux for 30 minutes. Filtration gave the title compound (1.56 g.). Recrystallization from methanol gave a product having a M.P. of 280°-285° C. with decomposition.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 30 minutes
  3. filtrationFiltration

출처 및 근거

ORD 기록
ord-685cc610624c441b8623e6cf12e2104e
출처 데이터셋
uspto-grants-1977_01
특허 번호
US04001238

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