2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline → HCID 21486847, 화합물

반응식

[CH2:1]([S:3][C:4]1[O:8][C:7]([C:9]([Cl:11])=[O:10])=[N:6][N:5]=1)[CH3:2].[NH2:12][C:13]1[C:22]2[C:17](=[CH:18][C:19]([O:25][CH3:26])=[C:20]([O:23][CH3:24])[CH:21]=2)[N:16]=[C:15]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)[N:14]=1>>[ClH:11].[NH2:12][C:13]1[C:22]2[C:17](=[CH:18][C:19]([O:25][CH3:26])=[C:20]([O:23][CH3:24])[CH:21]=2)[N:16]=[C:15]([N:27]2[CH2:32][CH2:31][N:30]([C:9]([C:7]3[O:8][C:4]([S:3][CH2:1][CH3:2])=[N:5][N:6]=3)=[O:10])[CH2:29][CH2:28]2)[N:14]=1

참가 물질

반응물 2

HCID 6162672-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline

HCID 211840515-(Ethylsulfanyl)-1,3,4-oxadiazole-2-carbonyl chloride

생성물 1

HCID 21486847HCID 21486847, 화합물

실험 절차

The title compound was prepared from 5-ethylthio-1,3,4-oxadiazole-2-carbonyl chloride (0.79 g., 4.1 mmole) and 4-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline (1.19 g., 4.1 mmole) following the procedure described in Example 1. The product had a M.P. of 246°-248.5° C.

출처 및 근거

ORD 기록: ord-a916eddcf97448a783b141be7a20837e
출처 데이터셋: uspto-grants-1977_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04001238

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