Isovincamine → Apovincamine

HRID 1414344

반응식

HRID 1414344 반응식
[CH3:1][CH2:2][C:3]12[CH2:21][C:20](O)([C:22]([O:24][CH3:25])=[O:23])[N:19]3[C:9]4=[C:10]([C:13]5[C:18]3=[CH:17][CH:16]=[CH:15][CH:14]=5)[CH2:11][CH2:12][N:7]([CH:8]14)[CH2:6][CH2:5][CH2:4]2>C(O)=O>[CH3:1][CH2:2][C@:3]12[CH:21]=[C:20]([C:22]([O:24][CH3:25])=[O:23])[N:19]3[C:9]4=[C:10]([CH2:11][CH2:12][N:7]([C@@H:8]14)[CH2:6][CH2:5][CH2:4]2)[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:18]=13

참가 물질

3

반응물 1

HCID 5668Isovincamine

생성물 1

HCID 71204Apovincamine수율 80.3%

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

A solution of 3.54 g (0.01 mol) of 16-epivincamine in 50 ml of formic acid is heated under reflux for 10 hours, under nitrogen. The formic acid is evaporated on a water bath in vacuo, the residue is dissolved in methylene chloride, and the latter solution is washed with a saturated solution of sodium bicarbonate and with water. The solution is dried over sodium sulphate and filtered, and the methylene chloride is evaporated from the filtrate. 2.7g (yield = 80%) of apovincamine are thus collected.

후처리

  1. temperatureunder reflux for 10 hours, under nitrogen
  2. customThe formic acid is evaporated on a water bath in vacuo
  3. dissolutionthe residue is dissolved in methylene chloride
  4. washthe latter solution is washed with a saturated solution of sodium bicarbonate and with water
  5. dry with materialThe solution is dried over sodium sulphate
  6. filtrationfiltered
  7. customthe methylene chloride is evaporated from the filtrate

출처 및 근거

ORD 기록
ord-9c7eaee7879a416981dc934ca6fde6c3
출처 데이터셋
uspto-grants-1977_01
특허 번호
US04001251

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