Isopropylamine → 1-Isopropylamino-3-(5-4'-methylhexylaminocarbonylthiazol-2-oxy)-2-propanol

HRID 1414598노트

반응식

HRID 1414598 반응식
[CH:1]([NH2:4])([CH3:3])[CH3:2].[O:5]1[CH:7]([CH2:8][O:9][C:10]2[S:11][C:12]([C:15]([NH:17][CH2:18][CH2:19][CH2:20][CH:21]([CH3:24])[CH2:22][CH3:23])=[O:16])=[CH:13][N:14]=2)[CH2:6]1>C(O)C>[CH:1]([NH:4][CH2:6][CH:7]([OH:5])[CH2:8][O:9][C:10]1[S:11][C:12]([C:15]([NH:17][CH2:18][CH2:19][CH2:20][CH:21]([CH3:24])[CH2:22][CH3:23])=[O:16])=[CH:13][N:14]=1)([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 6363IsopropylamineHCID 20328376N-(4-Methylhexyl)-2-[(oxiran-2-yl)methoxy]-1,3-thiazole-5-carboxamide

생성물 1

HCID 203285121-Isopropylamino-3-(5-4'-methylhexylaminocarbonylthiazol-2-oxy)-2-propanol

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

This example illustrates further methods according to the invention of preparing the compounds of formula I to the invention. In this example 0.6 g. of isopropylamine is added to a solution containing 0.3 g. of 1,2-epoxy-3-(5-4'-methylhexylaminocarbonylthiazol-2-oxy)-propane in 20 ml. of anhydrous absolute ethanol, and then allowed to stand for 12 hours at room temperature. The mixture is then evaporated to dryness and the resulting residue chromatographed on silica gel yielding 1-isopropylamino-3-(5-4'-methylhexylaminocarbonylthiazol-2-oxy)-2-propanol.

후처리

  1. customaccording to the invention of preparing the compounds of formula I to the invention
  2. additioncontaining 0.3 g
  3. customThe mixture is then evaporated to dryness
  4. customthe resulting residue chromatographed on silica gel

출처 및 근거

ORD 기록
ord-a25f0d63d25743ff821c5d9e551a7e25
출처 데이터셋
uspto-grants-1977_01
특허 번호
US04001421

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