Potassium Hydroxide → 3-Hydroxy-3-phenylpropanoic acid

HRID 1414753노트

반응식

HRID 1414753 반응식
[OH:1][CH:2]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH2:3][C:4]([O:6]CC)=[O:5].[OH-].[K+]>C(O)C>[OH:1][CH:2]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH2:3][C:4]([OH:6])=[O:5]

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 99818Ethyl 3-phenylhydracrylate, (+-)-

생성물 1

HCID 929593-Hydroxy-3-phenylpropanoic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Ethyl 3-hydroxy-3-phenylpropanoate (19 g, 0.1 mole) was refluxed in a solution of KOH (10 g, 0.2 mole) in ethanol for two hours. The solvent was removed in vacuo and the residue was dissolved in H2O. The H2O solution was extracted with ethyl ether, then acidified with 37% hydrochloric acid. The oily product was extracted out with chloroform and the chloroform was removed in vacuo to yield 10 g (62.5%).

후처리

  1. customThe solvent was removed in vacuo
  2. dissolutionthe residue was dissolved in H2O
  3. extractionThe H2O solution was extracted with ethyl ether
  4. extractionThe oily product was extracted out with chloroform
  5. customthe chloroform was removed in vacuo
  6. customto yield 10 g (62.5%)

출처 및 근거

ORD 기록
ord-cdcbffa4f09742e9845325766a34354c
출처 데이터셋
uspto-grants-1977_01
특허 번호
US04002660

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