참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | 4-Amino-3-nitrophenyl thiocyanate | HCID 104677 | — |
| 반응물 | 1,1,2,2-Tetrafluoro-3-iodopropane | HCID 542861 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-Nitro-4-[(2,2,3,3-tetrafluoropropyl)sulfanyl]aniline | HCID 20371139 | — |
반응 단계
5 G. of 1-amino-2-nitro-4-thiocyanatobenzene in 20 ml. of dimethylformamide is heated under nitrogen with 0.97 g. of sodium borohydride in 20 ml. of dimethylformamide at not greater than 30° C. The mixture is stirred at 15° to 20° C for 1 hour, then treated with 6 g. of 1-iodo-2,2,3,3-tetrafluoropropane. The mixture is heated to 100° C for 4 hours, then cooled and diluted with water. The mixture is extracted with chloroform and the chloroform is evaporated to yield a red oil. Chromatography on silica gel gives 2-nitro-4-(2,2,3,3-tetrafluoropropylthio) aniline.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04002640 |
|---|
| 출처 데이터셋 | uspto-grants-1977_01 |
|---|
| ORD ID | ord-ccc99bbf4b044356a10ede892ba8ca4f |
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| 출처 메모 | uspto-grants-1977_01 |
|---|
