Water → 1-Tert-butyl-3-(3-oxo-1-cyclohexene-1-yl)urea
반응식
[C:1]1(=O)[CH2:6][CH2:5][CH2:4][C:3](=[O:7])[CH2:2]1.[C:9]([NH:13][C:14]([NH2:16])=[O:15])([CH3:12])([CH3:11])[CH3:10].O>C1C=CC=CC=1.C1(C)C=CC(S(O)(=O)=O)=CC=1>[C:9]([NH:13][C:14]([NH:16][C:1]1[CH2:6][CH2:5][CH2:4][C:3](=[O:7])[CH:2]=1)=[O:15])([CH3:12])([CH3:11])[CH3:10]참가 물질
6
실험 절차
To a solution of 11.2 g of 1,3-cyclohexanedione in 250 ml of benzene is added 11.6 g tert-butylurea and 100 mg of p-toluenesulfonic acid. The solution is heated at reflux under nitrogen with water removal for three hours. At the end of this period the solution is cooled and the precipitated product removed by filtration. The precipitate is recrystallized from acetonitrile to give 14 g of 1-tert-butyl-3-(3-oxo-1-cyclohexene-1-yl)urea, m.p. 223°-225° C.
후처리
- temperatureThe solution is heated
- temperatureAt the end of this period the solution is cooled
- customthe precipitated product removed by filtration
- customThe precipitate is recrystallized from acetonitrile
출처 및 근거
- ORD 기록
- ord-8431755f137a43b69ed8b570e3c7ee3b
- 출처 데이터셋
- uspto-grants-1977_01
- 특허 번호
- US04002767
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