1-Diethylamino-6-(3,4-dimethoxyphenyl)hexan-3-one → 2-Ethylcyclopentane-1,3-dione

HRID 1414959

반응식

HRID 1414959 반응식
COC1C=[C:5]([CH2:11][CH2:12][CH2:13]C(=O)C=C)[CH:6]=[CH:7][C:8]=1[O:9]C.C[O:19]C1C=C(CCCC(=O)CCN(CC)CC)C=CC=1OC>[OH-].[K+]>[CH2:12]([CH:11]1[C:5](=[O:19])[CH2:6][CH2:7][C:8]1=[O:9])[CH3:13]

참가 물질

4

반응물 2

HCID 214854151-Diethylamino-6-(3,4-dimethoxyphenyl)hexan-3-oneHCID 214857326-(3,4-Dimethoxyphenyl)hex-1-en-3-one

생성물 1

HCID 699782-Ethylcyclopentane-1,3-dione

시약·촉매·용매 1

HCID 14797Potassium Hydroxide용매

실험 절차

Reflux 6-(3,4-dimethoxyphenyl)hex-1-en-3-one, containing a small amount of 6-(3,4-dimethoxyphenyl)-1-diethylaminohexan-3-one (6 g, produced by slow distillation of the latter substance) with 2-ethylcyclopentane-1,3-dione (3.5 g) in 0.12% anhydrous methanolic potassium hydroxide (10 cc) for 10 hours. Remove most of the methanol under reduced pressure, add benzene (25 cc) and ether (25 cc) and wash the solution with water, dilute aqueous potassium hydroxide, dilute hydrochloric acid and water. Dry and evaporate the solvent to give the triketone adduct 2-[6-(3,4-dimethoxyphenyl)-3-oxohexyl]-2-ethylcyclopentane-1,3-dione; infrared absorption (gum) 5.80, 6.25 μ (split peak).

출처 및 근거

ORD 기록
ord-237a621020b4448eb6466d47d36f2cc4
출처 데이터셋
uspto-grants-1977_01
특허 번호
US04002746

연결된 노트

불러오는 중…