Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → Levonorgestrel
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Levonorgestrel EP Impurity B | HCID 29979902 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Levonorgestrel | HCID 13109 | — |
반응 단계
Stir 13β-ethyl-17α-ethynyl-17β-hydroxy-gon-5(10)-en-3-one (0.1 g.) with a mixture of methanol (36 cc.), water (1.6 cc.) and concentrated hydrochloric acid (2.4 cc.) for 1 hour. Add water and extract the mixture with ether. Wash, dry and evaporate the ethereal solution and recrystallize the residue from ether-hexane to obtain the title compound, m.p. 203°-6° undepressed on admixture with authentic material. Infrared spectrum 3.05, 3.5, 6.05, 9.4 μ.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04002746 |
| 출처 데이터셋 | uspto-grants-1977_01 |
| ORD ID | ord-42832c707e07449bb437a10f30a9d7d3 |
| 출처 메모 | uspto-grants-1977_01 |