Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetyl chloride → Acetoacetic Acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetyl chloride | HCID 6367 | — |
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 반응물 | Levonorgestrel | HCID 13109 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | Acetoacetic Acid | HCID 96 | — |
| 생성물 | 13-Ethyl-17alpha-ethynyl-3,17-dihydroxygona-3,5-diene | HCID 86733490 | — |
반응 단계
Reflux dl-13-ethyl-17α-ethynyl-17β-hydroxygon-4-en-3-one (1.0 g) for 11/2 hours with acetic anhydride (16 cc), acetyl chloride (8.0 cc) and pyridine (0.8 cc). Remove the liquids under reduced pressure and partition the dry crystalline residue between benzene-ether and water. Wash the organic solvents under reduced pressure and triturate the residue with ice-cold ether to provide dl-13-ethyl-17α-ethynyl-3,17-dihydroxygona-3,5-diene, diacetate (0.725 g), m.p. 144°-150°C; λmax. KBr 3.09, 5.67, 5.77μ; λmax. EtOH 236 mμ (ε19,300).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04002746 |
| 출처 데이터셋 | uspto-grants-1977_01 |
| ORD ID | ord-9d1f304e52444deeb5fd680d48f38e5c |
| 출처 메모 | uspto-grants-1977_01 |