Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetaldehyde → Netilmicin
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetaldehyde | HCID 177 | — |
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Nitric Acid | HCID 944 | — |
| 반응물 | Phosphoric Acid | HCID 1004 | — |
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | p-Toluenesulfonic acid | HCID 6101 | — |
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | Sisomicin | HCID 36119 | — |
| 반응물 | Sodium cyanoborohydride | HCID 5003444 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Netilmicin | HCID 441306 | — |
반응 단계
in the procedure of above Example 1A instead of adding 1 N sulfuric acid to the solution of sisomicin in water until it reaches a pH of about 5, other acids may be used, such as acetic acid, trifluoroacetic acid, p-toluenesulfonic acid, hydrochloric acid, phosphoric acid, or nitric acid. The acidified aqueous solution is then treated with acetaldehyde and sodium cyanoborohydride and the resultant product is purified as described above, whereby is obtained 1-N-ethylsisomicin.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04002742 |
| 출처 데이터셋 | uspto-grants-1977_01 |
| ORD ID | ord-1cf3e61ee5494d7a91ba96e414aab62f |
| 출처 메모 | uspto-grants-1977_01 |