3-Nitrobenzaldehyde → 2-Amino-6-dimethylamino-4-(3'-nitrophenyl)-4,5-dihydropyridine-3,5-dicarboxylic acid diethyl ester

HRID 1415293노트

반응식

HRID 1415293 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH:7]=O)([O-:3])=[O:2].[CH2:12]([O:14][C:15](=[O:22])[CH:16]=[C:17]([N:19]([CH3:21])[CH3:20])[NH2:18])[CH3:13]>C(O)C>[CH2:12]([O:14][C:15]([C:16]1[CH:7]([C:6]2[CH:9]=[CH:10][CH:11]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=2)[CH:16]([C:15]([O:14][CH2:12][CH3:13])=[O:22])[C:17]([N:19]([CH3:20])[CH3:21])=[N:18][C:17]=1[NH2:18])=[O:22])[CH3:13]

참가 물질

4

반응물 2

HCID 74493-NitrobenzaldehydeHCID 867334643-Amino-3-dimethylaminoacrylic acid ethyl ester

생성물 1

HCID 124486892-Amino-6-dimethylamino-4-(3'-nitrophenyl)-4,5-dihydropyridine-3,5-dicarboxylic acid diethyl ester

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

After boiling a solution of 7.5 g of 3-nitrobenzaldehyde and 15.8 g of N,N-dimethyl-3,3-diaminoacrylic acid ethyl ester in 150 ml of ethanol for 4 hours, the solution was concentrated in vacuo. On triturating the resulting oil with ether, filtering off the crystals which separated out and crystallizing these from isopropanol, the yellow-orange colored crystals of 2-amino-6-dimethylamino-4-(3'-nitrophenyl)-4,5-dihydropyridine-3,5-dicarboxylic acid diethyl ester, of melting point 149° C, were obtained. Yield, 61% of theory.

후처리

  1. customfor 4 hours
  2. concentrationthe solution was concentrated in vacuo
  3. customOn triturating the resulting oil with ether
  4. filtrationfiltering off the crystals which
  5. customseparated out
  6. customcrystallizing these from isopropanol

출처 및 근거

ORD 기록
ord-45286f4ad3ae4df6a81171266e5ac153
출처 데이터셋
uspto-grants-1977_01
특허 번호
US04004014

반응 노트

불러오는 중…