Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acrylonitrile → 1-(3-Aminopropyl)-4-[2-(1,5-di-[3,3-dimethylbicyclo[2.2.1]hept-2-yl]-3-pentylamino)ethyl]piperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acrylonitrile | HCID 7855 | — |
| 반응물 | 4-Piperidineethanamine | HCID 1512602 | — |
| 반응물 | 1,5-Di-(3,3-dimethylnorborn-2-yl)-3-pentanone | HCID 21332846 | — |
| 생성물 | 1-(3-Aminopropyl)-4-[2-(1,5-di-[3,3-dimethylbicyclo[2.2.1]hept-2-yl]-3-pentylamino)ethyl]piperidine | HCID 21483969 | — |
반응 단계
As an alternative to obtaining a mixture of Schiff bases VI and VI(a) or VI(b), the reaction can be conducted stepwise. For example, 4-(2-aminoethyl)piperidine may be converted to a Schiff base with 1,5-di-[3,3-dimethylbicyclo[2.2.1]hept-2-yl]pentan-3-one, catalytically reduced, the ring nitrogen selectively cyanoethylated with acrylonitrile, followed by catalytic hydrogenation to furnish 1-(3-aminopropyl)-4-[2-(1,5-di-[3,3-dimethylbicyclo[2.2.1]hept-2-yl]-3-pentylamino)ethyl]piperidine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04003934 |
| 출처 데이터셋 | uspto-grants-1977_01 |
| ORD ID | ord-71023bb448a74992ad683619ac9ef9d1 |
| 출처 메모 | uspto-grants-1977_01 |