Triethylamine → 1-Methoxy-3-(1,2,3,4-tetrahydro-1-naphthyl)-thiourea

HRID 1415478

반응식

HRID 1415478 반응식
Cl.[CH3:2][O:3][NH2:4].C(N(CC)CC)C.[CH:12]1([N:22]=[C:23]=[S:24])[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:15][CH2:14][CH2:13]1>C(Cl)Cl>[CH3:2][O:3][NH:4][C:23]([NH:22][CH:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:15][CH2:14][CH2:13]1)=[S:24]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 521874O-Methylhydroxylamine hydrochlorideHCID 213934781-Isothiocyanato-1,2,3,4-tetrahydronaphthalene

생성물 1

HCID 213934961-Methoxy-3-(1,2,3,4-tetrahydro-1-naphthyl)-thiourea

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To an ice-cold, stirred mixture of 0.02 mole of methoxyamine hydrochloride and methylene chloride is added 0.02 mole of triethylamine. The mixture is then allowed to warm to about 15° to 25° C. while a solution of 0.01 mole of 1,2,3,4-tetrahydro-1-naphthyl isothiocyanate in methylene chloride is added dropwise. The mixture is stirred overnight at room temperature and then filtered. The filtrate is washed with water, dried (sodium sulfate), and the solvent evaporated at reduced pressure to give the title compound.

후처리

  1. additionis added dropwise
  2. filtrationfiltered
  3. washThe filtrate is washed with water
  4. dry with materialdried (sodium sulfate)
  5. customthe solvent evaporated at reduced pressure

출처 및 근거

ORD 기록
ord-fe2c7237231b464bbce50bf2fe5a121f
출처 데이터셋
uspto-grants-1977_01
특허 번호
US04005140

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