N-(2-nitrophenyl)-2-dimethylaminoacetamide → N-(2-aminophenyl)-2-(dimethylamino)acetamide

HRID 1415635노트

반응식

HRID 1415635 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][C:11](=[O:16])[CH2:12][N:13]([CH3:15])[CH3:14])([O-])=O.[H][H]>[Pt]=O.C(O)C>[NH2:1][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][C:11](=[O:16])[CH2:12][N:13]([CH3:14])[CH3:15]

참가 물질

5

반응물 2

HCID 2958870N-(2-nitrophenyl)-2-dimethylaminoacetamideHCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 16784338N-(2-aminophenyl)-2-(dimethylamino)acetamide수율 77.8%

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 702Ethanol용매

실험 절차

N-(2-nitrophenyl)-2-dimethylaminoacetamide (13.8 g), platinum oxide (0.2 g) and ethanol (100 ml) were mixed together and shaken in an atmosphere of hydrogen at atmospheric pressure and laboratory temperature until absorption of hydrogen ceased (4.5 litres of hydrogen were absorbed in 2hours). The mixture was then filtered and the ethanol evaporated off under reduced pressure. The solid residue so obtained was recrystallised from cyclohexane to give N-(2-aminophenyl)-2-dimethylaminoacetamide (9.3 g), m.p. 121°-123° C.

후처리

  1. custom(4.5 litres of hydrogen were absorbed in 2hours)
  2. filtrationThe mixture was then filtered
  3. customthe ethanol evaporated off under reduced pressure
  4. customThe solid residue so obtained
  5. customwas recrystallised from cyclohexane

출처 및 근거

ORD 기록
ord-3c74c1875df44f629e9d42366603f025
출처 데이터셋
uspto-grants-1977_01
특허 번호
US04005217

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