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N-(4-butyl-2-nitrophenyl)-2-(dimethylamino)acetamide → N-(2-amino-4-n-butylphenyl)-2-dimethylaminoacetamide

HRID 1415645
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반응식

HRID 1415645 반응식
[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:17])[CH2:13][N:14]([CH3:16])[CH3:15])=[C:7]([N+:18]([O-])=O)[CH:6]=1)[CH2:2][CH2:3][CH3:4].[H][H]>[Pt]=O.C(O)C>[NH2:18][C:7]1[CH:6]=[C:5]([CH2:1][CH2:2][CH2:3][CH3:4])[CH:10]=[CH:9][C:8]=1[NH:11][C:12](=[O:17])[CH2:13][N:14]([CH3:16])[CH3:15]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 21482988N-(4-butyl-2-nitrophenyl)-2-(dimethylamino)acetamideHCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 21482970N-(2-amino-4-n-butylphenyl)-2-dimethylaminoacetamide수율 74.7%

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 702Ethanol용매

실험 절차

N-(4-n-butyl-2-nitrophenyl)-2-dimethylaminoacetamide (36 g), prepared as described above, platinum oxide (0.2 g) and ethanol (100 ml) were shaken together in an atmosphere of hydrogen at laboratory temperature and atmospheric pressure until the uptake of hydrogen was complete; 8.2 litres were absorbed. The mixture was filtered and the ethanol evaporated off. The resultant solid was recrystallised from petroleum spirit (b.p. 60°-80° C.) to give N-(2-amino-4-n-butylphenyl)-2-dimethylaminoacetamide (24.0 g), m.p. 63°-66° C.

후처리

  1. custom8.2 litres were absorbed
  2. filtrationThe mixture was filtered
  3. customthe ethanol evaporated off
  4. customThe resultant solid was recrystallised from petroleum spirit (b.p. 60°-80° C.)

출처 및 근거

ORD 기록
ord-fb48f993c0a34ddf94d33727f3a403f5
출처 데이터셋
uspto-grants-1977_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04005217

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