Acetate-hydrochloric acid → 1-(3-Amino-4,6-difluorophenyl)-7-chloro-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

HRID 1415926

반응식

HRID 1415926 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([N:10]2[C:19]3[C:14](=[CH:15][C:16]([F:21])=[C:17]([Cl:20])[N:18]=3)[C:13](=[O:22])[C:12]([C:23]([O:25]CC)=[O:24])=[CH:11]2)[C:5]([F:9])=[CH:6][C:7]=1[F:8].Cl.C(O)(=O)C>O>[NH2:1][C:2]1[CH:3]=[C:4]([N:10]2[C:19]3[C:14](=[CH:15][C:16]([F:21])=[C:17]([Cl:20])[N:18]=3)[C:13](=[O:22])[C:12]([C:23]([OH:25])=[O:24])=[CH:11]2)[C:5]([F:9])=[CH:6][C:7]=1[F:8]

참가 물질

4

반응물 2

HCID 22641269Acetate-hydrochloric acidHCID 53833255Ethyl 1-(3-amino-4,6-difluorophenyl)-7-chloro-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate

생성물 1

HCID 110899701-(3-Amino-4,6-difluorophenyl)-7-chloro-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid수율 96.8%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To 0.6 g of ethyl 1-(3-amino-4,6-difluorophenyl)-7-chloro-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate was added 4 ml of a 3N hydrochloric acid/acetic acid mixture. The solution was heated at reflux for 2 hours. Distilled water (3 ml) was added to the solution, which was refluxed for 5 minutes. The precipitate was collected by filtration and washed with ethanol to give 0.54 g of the title compound.

후처리

  1. temperatureThe solution was heated
  2. temperatureat reflux for 2 hours
  3. temperaturewas refluxed for 5 minutes
  4. filtrationThe precipitate was collected by filtration
  5. washwashed with ethanol

출처 및 근거

ORD 기록
ord-615a00c25ab44f2f9c8282cad3cb2c6c
출처 데이터셋
uspto-grants-1999_06
특허 번호
US05910498

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