(5-(3,5-Dichlorophenylthio)-4-isopropyl-1-(2,2,2-trifluoroethyl)-1H-imidazol-2-yl)methanol → 2-Aminomethyl-5-(3,5-dichlorophenylthio)-4-isopropyl-1-(2,2,2-trifluoroethyl)-1H-imidazole

HRID 1416020노트

반응식

HRID 1416020 반응식
Cl[CH2:2][C:3]1[N:4]([CH2:20][C:21]([F:24])([F:23])[F:22])[C:5]([S:11][C:12]2[CH:17]=[C:16]([Cl:18])[CH:15]=[C:14]([Cl:19])[CH:13]=2)=[C:6]([CH:8]([CH3:10])[CH3:9])[N:7]=1.ClC1C=C(SC2N(CC(F)(F)F)C(CO)=[N:36]C=2C(C)C)C=C(Cl)C=1>>[NH2:36][CH2:2][C:3]1[N:4]([CH2:20][C:21]([F:22])([F:24])[F:23])[C:5]([S:11][C:12]2[CH:17]=[C:16]([Cl:18])[CH:15]=[C:14]([Cl:19])[CH:13]=2)=[C:6]([CH:8]([CH3:10])[CH3:9])[N:7]=1

참가 물질

3

반응물 2

HCID 473942(5-(3,5-Dichlorophenylthio)-4-isopropyl-1-(2,2,2-trifluoroethyl)-1H-imidazol-2-yl)methanolHCID 22130802HCID 22130802, 화합물

생성물 1

HCID 4739852-Aminomethyl-5-(3,5-dichlorophenylthio)-4-isopropyl-1-(2,2,2-trifluoroethyl)-1H-imidazole

실험 절차

2-Chloromethyl-5-(3,5-dichlorophenylthio)-4-isopropyl-1-(2,2,2-trifluoroethyl)-1H-imidazole (28k)was synthesized from [5-(3,5-dichlorophenylthio)-4-isopropyl-1-(2,2,2-trifluoroethyl)-1H-imidazol-2-yl]methanol (Compound I-33)by the same synthetic process as that for (28a)in Example 66, and without purification of this compound, 2-azidomethyl-5-(3,5-dichlorophenylthio)-4-isopropyl-1-(2,2,2-trifluoroethyl)-1H-imidazole (29k)was obtained by the same synthetic process as that for (29a)in Example 66. Oil.

후처리

  1. customthe same synthetic process as that for (28a)in Example 66, and without purification of this compound, 2-azidomethyl-5-(3,5-dichlorophenylthio)-4-isopropyl-1-(2,2,2-trifluoroethyl)-1H-imidazole (29k)was
  2. customobtained by the same synthetic process as that for (29a)in Example 66

출처 및 근거

ORD 기록
ord-01f3b1640a51477a8c46f86d6e2dbe0b
출처 데이터셋
uspto-grants-1999_06
특허 번호
US05910506

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