Ammonia → Imidazo[2,1-b]thiazole-6-methanol, 2,3-dihydro-, 1,1-dioxide

HRID 1416138노트

반응식

HRID 1416138 반응식
C([O:4][CH2:5][C:6]1[N:7]=[C:8]2[N:12]([CH:13]=1)[CH2:11][CH2:10][S:9]2(=[O:15])=[O:14])(=O)C.N>>[OH:4][CH2:5][C:6]1[N:7]=[C:8]2[N:12]([CH:13]=1)[CH2:11][CH2:10][S:9]2(=[O:15])=[O:14]

참가 물질

3

반응물 2

HCID 222AmmoniaHCID 18183092HCID 18183092, 화합물

생성물 1

HCID 18183097Imidazo[2,1-b]thiazole-6-methanol, 2,3-dihydro-, 1,1-dioxide

실험 절차

6-Acetoxymethyl-2,3-dihydroimidazo[2,1-b]thiazole-1,1-dioxide (305 mg, 1.33 mmol) was treated with methanolic ammonia (prepared by saturating methanol (20 ml) with ammonia gas then diluting with more methanol (20 ml)) at room temperature. After 2.5 h, the volatiles were removed under reduced pressure and the residue triturated with diethyl ether and the resulting solid collected by filtration, washed with diethyl ether and dried in air (207 mg, 83%) (Found: M+ 188.0256. C6H8N2O3S requires M 188.0256); nmax (nujol) 3354, 1377, 1325 and 1133 cm-1 ; dH [250 MHz; (CD3)2SO] 4.14 (2H, t, J 6Hz), 4.40 (2H, d, J 6Hz), 4.54 (2H, t, J 6Hz), 5.20 (1H, t, J 6Hz, exchangeable), 7.36 (1H, s).

후처리

  1. customprepared
  2. concentrationby saturating methanol (20 ml) with ammonia gas
  3. additionthen diluting with more methanol (20 ml)) at room temperature
  4. customthe volatiles were removed under reduced pressure
  5. customthe residue triturated with diethyl ether
  6. filtrationthe resulting solid collected by filtration
  7. washwashed with diethyl ether
  8. customdried in air (207 mg, 83%) (Found: M+ 188.0256. C6H8N2O3S requires M 188.0256)

출처 및 근거

ORD 기록
ord-f69eaff3f92e420d9c0af0922e1325f8
출처 데이터셋
uspto-grants-1999_06
특허 번호
US05911985

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