Triethylamine → 3,3-Dimethylbutyl methanesulfonate
반응식
[CH3:1][C:2]([CH3:7])([CH3:6])[CH2:3][CH2:4][OH:5].C(N(CC)CC)C.[CH3:15][S:16](Cl)(=[O:18])=[O:17]>ClCCl>[CH3:15][S:16]([O:5][CH2:4][CH2:3][C:2]([CH3:7])([CH3:6])[CH3:1])(=[O:18])=[O:17]참가 물질
5
실험 절차
To a stirred solution of 3,3-dimethyl-1-butanol (2 ml) in dichloromethane (48 ml), under nitrogen, was added triethylamine (4.64 ml) and the resulting solution cooled to 0/C. Methanesulphonylchloride (1.28 ml) was then added dropwise via syringe and stirring continued for 18 h as the reaction warmed to room temperature. The reaction was then concentrated onto silica and purified by flash chromatography to give the title compound as a yellow oil.
후처리
- temperaturethe resulting solution cooled to 0/C
- concentrationThe reaction was then concentrated onto silica
- custompurified by flash chromatography
출처 및 근거
- ORD 기록
- ord-e27acd651a474426b355d3f6d72b6602
- 출처 데이터셋
- uspto-grants-1999_06
- 특허 번호
- US05912252
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