참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Piperazine | HCID 4837 | — |
| 반응물 | 2,4-Difluorobenzonitrile | HCID 77545 | — |
| 용매 | Dimethylacetamide | HCID 31374 | — |
| 생성물 | 4-Fluoro-2-(piperazin-1-yl)benzonitrile | HCID 19367108 | — |
반응 단계
A mixture of piperazine (Aldrich; 3.99 g), 2,4-difluorobenzonitrile, and N,N-dimethylacetamide (20 mL) is stirred for 1.5 h at 122° C. After cooling, the mixture is partitioned between dichloromethane and satd. aq. sodium bicarbonate. The organic layers are dried over magnesium sulfate and concentrated. The residue is chromatographed on silica gel and the appropriate fractions are combined and concentrated to give 1.44 g of 1-(2-cyano-5-fluorophenyl)piperazine; 1H NMR (CDCl3) δ3.01, 3.30, 6.56, 6.63, 7.40.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05912246 |
|---|
| 출처 데이터셋 | uspto-grants-1999_06 |
|---|
| ORD ID | ord-5980976b2f5f4071b3a4e96b7f854466 |
|---|
| 출처 메모 | uspto-grants-1999_06 |
|---|
