5,6-Dimethylbenzimidazole → 1H-Furo[3,4-f]benzimidazole-5,7-dione

반응식

[N:1]1[C:5]2[CH:6]=[C:7]([C:13]([OH:15])=[O:14])[C:8]([C:10]([OH:12])=O)=[CH:9][C:4]=2[NH:3][CH:2]=1.CC1C(C)=CC2N=CNC=2C=1>>[N:3]1[C:4]2[CH:9]=[C:8]3[C:10](=[O:12])[O:15][C:13](=[O:14])[C:7]3=[CH:6][C:5]=2[NH:1][CH:2]=1

참가 물질

반응물 2

HCID 6755,6-Dimethylbenzimidazole

HCID 7023591Benzimidazole-5,6-dicarboxylic acid

생성물 1

HCID 108452781H-Furo[3,4-f]benzimidazole-5,7-dione수율 81.5%

반응 조건

온도: 250 °C

실험 절차

Benzimidazole-5,6-dicarboxylic acid (8.2 g), prepared from 5,6-dimethylbenzimidazole as described in J.Org.Chem. 1987, 52, 2934., was heated at 250° C. under vacuum (0.01 mm Hg) for 1 h. The solid was extracted with hot acetone and the acetone extracts were evaporated to give the title compound (6.1 g).

후처리

extractionThe solid was extracted with hot acetone
customthe acetone extracts were evaporated

출처 및 근거

ORD 기록: ord-8d039b3793844ab9a102886c2463afb6
출처 데이터셋: uspto-grants-1999_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05912260

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