Acetone → 4-[trans-(2-Hydroxycyclopentan-1-yl)oxy]-2-(1-piperazinyl)quinazoline monoacetate

HRID 1416446노트

반응식

HRID 1416446 반응식
[OH:1][C@@H:2]1[CH2:6][CH2:5][CH2:4][C@H:3]1[O:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=[C:10]([N:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[N:9]=1.CC(C)=[O:26]>>[C:8]([OH:26])(=[O:7])[CH3:17].[OH:1][C@@H:2]1[CH2:6][CH2:5][CH2:4][C@H:3]1[O:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=[C:10]([N:18]2[CH2:19][CH2:20][NH:21][CH2:22][CH2:23]2)[N:9]=1

참가 물질

3

반응물 2

HCID 180AcetoneHCID 154091264-[trans-(2-Hydroxycyclopentan-1-yl)oxy]-2-(1-piperazinyl)quinazoline

생성물 1

HCID 675829364-[trans-(2-Hydroxycyclopentan-1-yl)oxy]-2-(1-piperazinyl)quinazoline monoacetate

실험 절차

4-[trans-(2-Hydroxycyclopentan-1-yl)oxy]-2-(1-piperazinyl)quinazoline (cf. Example 1) (2.70 g) is dissolved in acetone (55 ml) with heating, and the solution is filtered, and to the filtrate is added acetic acid (0.52 ml), and the mixture is allowed to stand at room temperature. The precipitated crystals are separated by filtration to give 4-[trans-(2-hydroxycyclopentan-1-yl)oxy]-2-(1-piperazinyl)quinazoline monoacetate (3.00 g) as crystals.

후처리

  1. temperaturewith heating
  2. filtrationthe solution is filtered
  3. additionto the filtrate is added acetic acid (0.52 ml)
  4. customto stand at room temperature
  5. customThe precipitated crystals are separated by filtration

출처 및 근거

ORD 기록
ord-0a52329be9fa468d8f75bb294df38491
출처 데이터셋
uspto-grants-1999_06
특허 번호
US05912247

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