HCID 67581870, 화합물 → HCID 57011354, 화합물
반응식
C(OC([N:11]1[CH2:16][CH2:15][N:14]([C:17]2[N:26]=[C:25]([O:27][C@@H:28]3[CH2:32][C@H:31]([O:33][CH3:34])[C@@H:30]([OH:35])[C@H:29]3[OH:36])[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[N:18]=2)[CH2:13][CH2:12]1)=O)C1C=CC=CC=1>CO.[Pd]>[OH:36][C@@H:29]1[C@H:30]([OH:35])[C@@H:31]([O:33][CH3:34])[CH2:32][C@H:28]1[O:27][C:25]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[N:18]=[C:17]([N:14]2[CH2:13][CH2:12][NH:11][CH2:16][CH2:15]2)[N:26]=1참가 물질
4
실험 절차
To a solution of 2-[4-(benzyloxycarbonyl)piperazin-1-yl]-4-[(1R,2R,3S,4S)-(2,3-dihydroxy-4-methoxycyclopentan-1-yl)oxy]quinazoline (5.40 g) in methanol (108 ml) is added 10% palladium/carbon (1.00 g), and the mixture is stirred under hydrogen atmosphere and under atmospheric pressure at room temperature for 16.5 hours. The reaction mixture is filtered, and the filtrate is evaporated to dryness under reduced pressure, and the residue is crystallized from diethyl ether to give 4-[(1R,2R,3S,4S)-(2,3-dihydroxy-4-methoxycyclopentan-1-yl)oxy]-2-(1-piperazinyl)quinazoline (2.95 g) as crystals. A part of this product is recrystallized from ethanol-diethyl ether to give a pure crystalline product, which has the following physical properties.