Hydrochloride methanol → HCID 67583545, 화합물

HRID 1416507노트

반응식

HRID 1416507 반응식
[OH:1][C@@H:2]([C@H:21]([OH:24])[CH2:22][OH:23])[CH2:3][O:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[C:7]([N:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[N:6]=1.[ClH:25].CO>CO>[ClH:25].[OH:1][C@@H:2]([C@H:21]([OH:24])[CH2:22][OH:23])[CH2:3][O:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[C:7]([N:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[N:6]=1

참가 물질

4

반응물 2

HCID 21893726Hydrochloride methanolHCID 54235254HCID 54235254, 화합물

생성물 1

HCID 67583545HCID 67583545, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

4-[(2R,3R)-(2,3,4-Trihydroxybutan-1-yl)oxy]-2-(1-piperazinyl)quinazoline (cf Example 64) (0.5 g) is dissolved in methanol (40 ml), and thereto is added 2N HCl-methanol (0.82 ml), and the mixture is evaporated to dryness under reduced pressure. The resulting residue is recrystallized from ethanol to give 4-[(2R,3R)-(2,3,4-trihydroxybutan-1-yl)oxy]-2-(1-piperazinyl)quinazoline monohydrochloride (0.14 g).

후처리

  1. customthe mixture is evaporated to dryness under reduced pressure
  2. customThe resulting residue is recrystallized from ethanol

출처 및 근거

ORD 기록
ord-06f34af567b245959df6c6b0b9bbff79
출처 데이터셋
uspto-grants-1999_06
특허 번호
US05912247

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