Ammonia → HCID 54274160, 화합물

To an icecooled solution of 1-formyl-4-azatricyclo[2.2.1.02,6 ]heptane (3.56 g, 29 mmol) in water (5 ml) was added a solution of potassium cyanide (2.08 g, 31.9 mmol) in water (5 ml) over 30 min. After an additional 1 h, cooling was removed and the reaction stirred at room temperature for 16 h. The cyanohydrin product was then added 25% aqueous ammonia (4.0 ml, 52 mmol) and ammonium chloride (7.76 g, 145 mmol). The reaction mixture was stirred at room temperature for 18 h and then extracted with isopropanole/dichloromethane (1:10) (10×75 ml). The organic phases were dried and evaporated to give the title compound as an oil (2.5 g, 58%).

1. temperaturecooling
2. customwas removed
3. stirringThe reaction mixture was stirred at room temperature for 18 h
4. extractionextracted with isopropanole/dichloromethane (1:10) (10×75 ml)
5. customThe organic phases were dried
6. customevaporated

ORD 기록

ord-cc9378448944404c835f9c103736cf34

출처 데이터셋

uspto-grants-1999_06

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US05914338