Trifluoroacetic acid → D-Phe-Pro-OBn.TFA

HRID 1416576노트

반응식

HRID 1416576 반응식
[NH:1](C(OC(C)(C)C)=O)[C@@H:2]([C:10]([N:12]1[CH2:26][CH2:25][CH2:24][C@H:13]1[C:14]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.C1(OC)C=CC=CC=1.[F:42][C:43]([F:48])([F:47])[C:44]([OH:46])=[O:45]>ClCCl>[NH2:1][C@@H:2]([C:10]([N:12]1[CH2:26][CH2:25][CH2:24][C@H:13]1[C:14]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[F:42][C:43]([C:44]([OH:46])=[O:45])([F:48])[F:47]

참가 물질

5

반응물 3

HCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 11155205Boc-(D)Phe-Pro-OBzl

생성물 1

HCID 131720381D-Phe-Pro-OBn.TFA수율 85%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a stirring solution of Boc-D-Phe-Pro-OBn (68 g, 150 mmol) in dichloromethane (50 mL) at 0° C., was added anisole (20 mL) followed by trifluoroacetic acid (400 mL). After stirring for 3 hours, the solvents were evaporated in vacuo and the thick oily residue was dissolved in diethyl ether (1.5 L) and refrigerated (72 hours). The white precipitate was filtered, washed with diethyl ether (300 mL) and dried to yield 59.4 g (85%) of white powder.

후처리

  1. customthe solvents were evaporated in vacuo
  2. dissolutionthe thick oily residue was dissolved in diethyl ether (1.5 L)
  3. custom(72 hours)
  4. filtrationThe white precipitate was filtered
  5. washwashed with diethyl ether (300 mL)
  6. customdried

출처 및 근거

ORD 기록
ord-c8617a70bdbf4897a3b485387dc888da
출처 데이터셋
uspto-grants-1999_06
특허 번호
US05914319

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